Quantitative susceptibility mapping (QSM): Decoding MRI data for a tissue magnetic biomarker.

ABSTRACT: In MRI, the main magnetic field polarizes the electron cloud of a molecule, generating a chemical shift for observer protons within the molecule and a magnetic susceptibility inhomogeneity field for observer protons outside the molecule. The number of water protons surrounding a molecule for detecting its magnetic susceptibility is vastly greater than the number of protons within the molecule for detecting its chemical shift. However, the study of tissue magnetic susceptibility has been hindered by poor molecular specificities of hitherto used methods based on MRI signal phase and T2* contrast, which depend convolutedly on surrounding susceptibility sources. Deconvolution of the MRI signal phase can determine tissue susceptibility but is challenged by the lack of MRI signal in the backgrou

SUBMITTER: Wang Y 

PROVIDER: S-EPMC4297605 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature