Adrenergic receptor genotype influences heart failure severity and β-blocker response in children with dilated cardiomyopathy.

ABSTRACT:

Background

Adrenergic receptor (ADR) genotypes are associated with heart failure (HF) and β-blocker response in adults. We assessed the influence of ADR genotypes in children with dilated cardiomyopathy (DCM).

Methods

Ninety-one children with advanced DCM and 44 with stable DCM were genotyped for three ADR genotypes associated with HF risk in adults: α2cdel322-325, β1Arg389, and β2Arg16. Data were analyzed by genotype and β-blocker use. Mean age at enrollment was 8.5 y.

Results

One-year event-free survival was 51% in advanced and 80% in stable DCM. High-risk genotypes were associated with higher left ventricular (LV) filling pressures, higher systemic and pulmonary vascular resistance, greater decline in LV ejection fraction (P < 0.05), and a higher frequency of mecha

SUBMITTER: Reddy S 

PROVIDER: S-EPMC4298011 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature