Efficacy of metformin in pregnant obese women: a randomised controlled trial.

ABSTRACT:

Introduction

Increasing evidence suggests obesity has its origins prior to birth. There is clear correlation between maternal obesity, high birthweight and offspring risk of obesity in later life. It is also clear that women who are obese during pregnancy are at greater risk of adverse outcomes, including gestational diabetes and stillbirth. The mechanism(s) by which obesity causes these problems is unknown, although hyperglycaemia and insulin resistance are strongly implicated. We present a protocol for a study to test the hypothesis that metformin will improve insulin sensitivity in obese pregnant women, thereby reducing the incidence of high birthweight babies and other pregnancy complications.

Methods and analysis

The Efficacy of Metformin in Pregnant Obese Women, a Rand

SUBMITTER: Chiswick CA 

PROVIDER: S-EPMC4298109 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature