Association of Nrf2 polymorphism haplotypes with acute lung injury phenotypes in inbred strains of mice.

ABSTRACT:

Aims

Nrf2 is a master transcription factor for antioxidant response element (ARE)-mediated cytoprotective gene induction. A protective role for pulmonary Nrf2 was determined in model oxidative disorders, including hyperoxia-induced acute lung injury (ALI). To obtain additional insights into the function and genetic regulation of Nrf2, we assessed functional single nucleotide polymorphisms (SNPs) of Nrf2 in inbred mouse strains and tested whether sequence variation is associated with hyperoxia susceptibility.

Results

Nrf2 SNPs were compiled from publicly available databases and by re-sequencing DNA from inbred strains. Hierarchical clustering of Nrf2 SNPs categorized the strains into three major haplotypes. Hyperoxia susceptibility was greater in haplotypes 2 and 3 strains th

SUBMITTER: Cho HY 

PROVIDER: S-EPMC4298158 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature