Patterns of linkage disequilibrium and long range hitchhiking in evolving experimental Drosophila melanogaster populations.

ABSTRACT: Whole-genome resequencing of experimental populations evolving under a specific selection regime has become a popular approach to determine genotype-phenotype maps and understand adaptation to new environments. Despite its conceptual appeal and success in identifying some causative genes, it has become apparent that many studies suffer from an excess of candidate loci. Several explanations have been proposed for this phenomenon, but it is clear that information about the linkage structure during such experiments is needed. Until now only Pool-Seq (whole-genome sequencing of pools of individuals) data were available, which do not provide sufficient information about the correlation between linked sites. We address this problem in two complementary analyses of three replicate Drosophila mela

SUBMITTER: Franssen SU 

PROVIDER: S-EPMC4298179 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature