Variation in Drosophila melanogaster central metabolic genes appears driven by natural selection both within and between populations.

ABSTRACT: In this report, we examine the hypothesis that the drivers of latitudinal selection observed in the eastern US Drosophila melanogaster populations are reiterated within seasons in a temperate orchard population in Pennsylvania, USA. Specifically, we ask whether alleles that are apparently favoured in northern populations are also favoured early in the spring, and decrease in frequency from the spring to autumn with the population expansion. We use SNP data collected for 46 metabolic genes and 128 SNPs representing the central metabolic pathway and examine for the aggregate SNP allele frequencies whether the association of allele change with latitude and that with increasing days of spring-autumn season are reversed. Testing by random permutation, we observe a highly significant negative co

SUBMITTER: Cogni R 

PROVIDER: S-EPMC4298213 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature