Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates.

ABSTRACT: Singly and multiply modified synthetic siRNA oligonucleotides, containing isomorphic surrogate nucleobases, show high interference potency in cell culture, suggesting the highly isomorphic RNA alphabet, based on a thieno[3,4-d]-pyrimidine core, is tolerated well by the cellular silencing machinery.

SUBMITTER: Shin D 

PROVIDER: S-EPMC4298453 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature