PET/CT imaging reveals unrivaled placental avidity for glucose compared to other tissues.

ABSTRACT:

Introduction

The goal of this study was to define the kinetics of glucose transport from maternal blood to placenta to fetus using real time imaging.

Methods

Positron emission tomography (PET) imaging of the glucose-tracer [(18)F]fluorodeoxyglucose (FDG) was used to temporally and spatially define, in vivo, the kinetics of glucose transport from maternal blood into placentae and fetuses, in the late gestational gravid rat. Computed tomography (CT), with intravenous contrast, co-registered to the PET images allowed anatomic differentiation of placentae from fetal and maternal tissues.

Results

FDG was rapidly taken up by placentae and subsequently appeared in fetuses with minimal temporal lag. FDG standardized uptake values in placentae and fetuses approached that of ma

SUBMITTER: Sawatzke AB 

PROVIDER: S-EPMC4298476 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature