Minireview: SLCO and ABC transporters: a role for steroid transport in prostate cancer progression.

ABSTRACT: Androgens play a critical role in the development and progression of prostate cancer (PCa), and androgen deprivation therapy via surgical or medical castration is front-line therapy for patients with advanced PCa. However, intratumoral testosterone levels are elevated in metastases from patients with castration-resistant disease, and residual intratumoral androgens have been implicated in mediating ligand-dependent mechanisms of androgen receptor activation. The source of residual tissue androgens present despite castration has not been fully elucidated, but proposed mechanisms include uptake and conversion of adrenal androgens, such as dehdroepiandrosterone to testosterone and dihydrotestosterone, or de novo androgen synthesis from cholesterol or progesterone precursors. In this minirevie

SUBMITTER: Cho E 

PROVIDER: S-EPMC4298565 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature