Genetic risk factors for the development of allergic disease identified by genome-wide association.

ABSTRACT: An increasing proportion of the worldwide population is affected by allergic diseases such as allergic rhinitis (AR), atopic dermatitis (AD) and allergic asthma and improved treatment options are needed particularly for severe, refractory disease. Allergic diseases are complex and development involves both environmental and genetic factors. Although the existence of a genetic component for allergy was first described almost 100 years ago, progress in gene identification has been hindered by lack of high throughput technologies to investigate genetic variation in large numbers of subjects. The development of Genome-Wide Association Studies (GWAS), a hypothesis-free method of interrogating large numbers of common variants spanning the entire genome in disease and non-disease subjects has rev

SUBMITTER: Portelli MA 

PROVIDER: S-EPMC4298800 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature