Childhood-onset asthma in smokers. association between CT measures of airway size, lung function, and chronic airflow obstruction.

ABSTRACT:

Rationale and objectives

Asthma is associated with chronic airflow obstruction. Our goal was to assess the association of computed tomographic measures of airway wall volume and lumen volume with the FEV1 and chronic airflow obstruction in smokers with childhood-onset asthma.

Methods

We analyzed clinical, lung function, and volumetric computed tomographic airway volume data from 7,266 smokers, including 590 with childhood-onset asthma. Small wall volume and small lumen volume of segmental airways were defined as measures 1 SD below the mean. We assessed the association between small wall volume, small lumen volume, FEV1, and chronic airflow obstruction (post-bronchodilator FEV1/FVC ratio < 0.7) using linear and logistic models.

Measurements and main results

Compared w

SUBMITTER: Diaz AA 

PROVIDER: S-EPMC4298990 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature