Cohort of birth modifies the association between FTO genotype and BMI.

ABSTRACT: A substantial body of research has explored the relative roles of genetic and environmental factors on phenotype expression in humans. Recent research has also sought to identify gene-environment (or g-by-e) interactions, with mixed success. One potential reason for these mixed results may relate to the fact that genetic effects might be modified by changes in the environment over time. For example, the noted rise of obesity in the United States in the latter part of the 20th century might reflect an interaction between genetic variation and changing environmental conditions that together affect the penetrance of genetic influences. To evaluate this hypothesis, we use longitudinal data from the Framingham Heart Study collected over 30 y from a geographically relatively localized sample to

SUBMITTER: Rosenquist JN 

PROVIDER: S-EPMC4299180 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature