Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM.

ABSTRACT: During somitogenesis, epithelial somites form from the pre-somitic mesoderm (PSM) in a periodic manner. This periodicity is regulated by a molecular oscillator, known as the 'segmentation clock', that is characterised by an oscillatory pattern of gene expression that sweeps the PSM in a caudal-rostral direction. Key components of the segmentation clock are intracellular components of the Notch, Wnt and FGF pathways, and it is widely accepted that intracellular negative-feedback loops regulate oscillatory gene expression. However, an open question in the field is how intracellular oscillations are coordinated, in the form of spatiotemporal waves of expression, across the PSM. In this study, we provide a potential mechanism for this process. We show at the mRNA level that the Notch1 receptor

SUBMITTER: Bone RA 

PROVIDER: S-EPMC4299275 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature