Continuous Flow Aerobic Alcohol Oxidation Reactions Using a Heterogeneous Ru(OH) _x /Al₂O₃ Catalyst.

ABSTRACT: Ru(OH) _x /Al₂O₃ is among the more versatile catalysts for aerobic alcohol oxidation and dehydrogenation of nitrogen heterocycles. Here, we describe the translation of batch reactions to a continuous-flow method that enables high steady-state conversion and single-pass yields in the oxidation of benzylic alcohols and dehydrogenation of indoline. A dilute source of O₂ (8% in N₂) was used to ensure that the reaction mixture, which employs toluene as the solvent, is nonflammable throughout the process. A packed bed reactor was operated isothermally in an up-flow orientation, allowing good liquid-solid contact. Deactivation of the catalyst during the reaction was modeled empirically, and this model was used to achieve high conversion

SUBMITTER: Mannel DS 

PROVIDER: S-EPMC4299400 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature