Ontology highlight
ABSTRACT:
SUBMITTER: Kotte O
PROVIDER: S-EPMC4299493 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Molecular systems biology 20140701
Fluctuations in intracellular molecule abundance can lead to distinct, coexisting phenotypes in isogenic populations. Although metabolism continuously adapts to unpredictable environmental changes, and although bistability was found in certain substrate-uptake pathways, central carbon metabolism is thought to operate deterministically. Here, we combine experiment and theory to demonstrate that a clonal Escherichia coli population splits into two stochastically generated phenotypic subpopulations ...[more]