Minimal metabolic pathway structure is consistent with associated biomolecular interactions.

ABSTRACT: Pathways are a universal paradigm for functionally describing cellular processes. Even though advances in high-throughput data generation have transformed biology, the core of our biological understanding, and hence data interpretation, is still predicated on human-defined pathways. Here, we introduce an unbiased, pathway structure for genome-scale metabolic networks defined based on principles of parsimony that do not mimic canonical human-defined textbook pathways. Instead, these minimal pathways better describe multiple independent pathway-associated biomolecular interaction datasets suggesting a functional organization for metabolism based on parsimonious use of cellular components. We use the inherent predictive capability of these pathways to experimentally discover novel transcripti

SUBMITTER: Bordbar A 

PROVIDER: S-EPMC4299494 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature