Systems and photosystems: cellular limits of autotrophic productivity in cyanobacteria.

ABSTRACT: Recent advances in the modeling of microbial growth and metabolism have shown that growth rate critically depends upon the optimal allocation of finite proteomic resources among different cellular functions and that modeling growth rates becomes more realistic with the explicit accounting for the costs of macromolecular synthesis, most importantly, protein expression. The "proteomic constraint" is considered together with its application to understanding photosynthetic microbial growth. The central hypothesis is that physical limits of cellular space (and corresponding solvation capacity) in conjunction with cell surface-to-volume ratios represent the underlying constraints on the maximal rate of autotrophic microbial growth. The limitation of cellular space thus constrains the size the to

SUBMITTER: Burnap RL 

PROVIDER: S-EPMC4299538 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature