Validation of serum biomarkers derived from proteomic analysis for the early screening of preeclampsia.

ABSTRACT:

Aim

To examine the potential value of previously identified biomarkers using proteomics in early screening for preeclampsia (PE).

Methods

24 blood samples from women who subsequently developed PE and 48 from uncomplicated pregnancies were obtained at 11-13 weeks and analysed after delivery. Cystatin-C, sVCAM-1, and Pappalysin-1 were quantified by ELISA. Maternal characteristics and medical history were recorded.

Results

Median values of Cystatin-C, sVCAM-1, and Pappalysin-1 in the PE group as compared to controls were 909.1 gEq/mL versus 480.0 gEq/mL, P = .000, 832.0 gEq/mL versus 738.8 gEq/mL, P = .024, and 234.4 gEq/mL versus 74.9 gEq/mL, P = .064, respectively. Areas under the receiver-operating characteristic curves (AUC, standard error (SE)) for predicting PE wer

SUBMITTER: Kolialexi A 

PROVIDER: S-EPMC4299787 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature