Neuroimaging abnormalities, neurocognitive function, and fatigue in patients with hepatitis C.

ABSTRACT:

Objective

This study examined neurologic abnormalities (as measured by proton magnetic resonance spectroscopy imaging and diffusion tensor imaging), neurocognitive performance, and fatigue among a sample of adults with hepatitis C virus (HCV). We hypothesized that HCV+ individuals would demonstrate structural brain abnormalities and neurocognitive compromise consistent with frontostriatal dysfunction as well as increased fatigue compared to controls.

Method

Participants were 76 individuals diagnosed with HCV and 20 controls who underwent a comprehensive neurocognitive evaluation and clinical assessments. A subset of the HCV+ participants (n = 29) and all controls underwent MRI.

Results

Individuals diagnosed with chronic HCV infection demonstrated greater fractional an

SUBMITTER: Thames AD 

PROVIDER: S-EPMC4299885 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature