Hyperconnectivity in juvenile myoclonic epilepsy: a network analysis.

ABSTRACT:

Objective

Juvenile myoclonic epilepsy (JME) is a common idiopathic (genetic) generalized epilepsy (IGE) syndrome characterized by impairments in executive and cognitive control, affecting independent living and psychosocial functioning. There is a growing consensus that JME is associated with abnormal function of diffuse brain networks, typically affecting frontal and fronto-thalamic areas.

Methods

Using diffusion MRI and a graph theoretical analysis, we examined bivariate (network-based statistic) and multivariate (global and local) properties of structural brain networks in patients with JME (N = 34) and matched controls. Neuropsychological assessment was performed in a subgroup of 14 patients.

Results

Neuropsychometry revealed impaired visual memory and naming in J

SUBMITTER: Caeyenberghs K 

PROVIDER: S-EPMC4299970 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature