Increased cortical surface area and gyrification following long-term survival from early monocular enucleation.

ABSTRACT:

Purpose

Retinoblastoma is typically diagnosed before 5 years of age and is often treated by enucleation (surgical removal) of the cancerous eye. Here, we sought to characterize morphological changes of the cortex following long-term survival from early monocular enucleation.

Methods

Nine adults with early right-eye enucleation (≤48 months of age) due to retinoblastoma were compared to 18 binocularly intact controls. Surface area, cortical thickness, and gyrification estimates were obtained from T1 weighted images and group differences were examined.

Results

Early monocular enucleation was associated with increased surface area and/or gyrification in visual (i.e., V1, inferior temporal), auditory (i.e., supramarginal), and multisensory (i.e., superior temporal, inferio

SUBMITTER: Kelly KR 

PROVIDER: S-EPMC4300017 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature