Acute cutaneous wounds treated with human decellularised dermis show enhanced angiogenesis during healing.

ABSTRACT:

Background

The influence of skin substitutes upon angiogenesis during wound healing is unclear.

Objectives

To compare the angiogenic response in acute cutaneous human wounds treated with autogenic, allogenic and xenogenic skin substitutes to those left to heal by secondary intention.

Methods

On day 0, four 5mm full-thickness punch biopsies were harvested from fifty healthy volunteers (sites 1-4). In all cases, site 1 healed by secondary intention (control), site 2 was treated with collagen-GAG scaffold (CG), cadaveric decellularised dermis (DCD) was applied to site 3, whilst excised tissue was re-inserted into site 4 (autograft). Depending on study group allocation, healing tissue from sites 1-4 was excised on day 7, 14, 21 or 28. All specimens were bisected, with hal

SUBMITTER: Greaves NS 

PROVIDER: S-EPMC4300088 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature