Bronchoalveolar lavage cell immunophenotyping facilitates diagnosis of lung allograft rejection.

ABSTRACT: Supplementary methods to identify acute rejection and to distinguish rejection from infection may improve clinical outcomes for lung allograft recipients. We hypothesized that distinct bronchoalveolar lavage (BAL) cell profiles are associated with rejection and infection. We retrospectively compared 2939 BAL cell counts and immunophenotypes against concomitantly obtained transbronchial biopsies and microbiologic studies. We randomly assigned 317 subjects to a derivation or validation cohort. BAL samples were classified into four groups: infection, rejection grade ≥A1, both or neither. We employed generalized estimating equation and survival modeling to identify clinical predictors of rejection and infection. We found that CD25(+) and natural killer cell percentages identified a twofold inc

SUBMITTER: Greenland JR 

PROVIDER: S-EPMC4300200 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature