Ontology highlight
ABSTRACT:
SUBMITTER: Aymard F
PROVIDER: S-EPMC4300393 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20140323 4
Although both homologous recombination (HR) and nonhomologous end joining can repair DNA double-strand breaks (DSBs), the mechanisms by which one of these pathways is chosen over the other remain unclear. Here we show that transcriptionally active chromatin is preferentially repaired by HR. Using chromatin immunoprecipitation-sequencing (ChIP-seq) to analyze repair of multiple DSBs induced throughout the human genome, we identify an HR-prone subset of DSBs that recruit the HR protein RAD51, unde ...[more]