Bisoprolol and bisoprolol-valsartan compatibility studied by differential scanning calorimetry, nuclear magnetic resonance and X-ray powder diffractometry.

ABSTRACT:

Purpose

The objective of this study was to evaluate the thermal behavior of crystalline and amorphous bisoprolol fumarate and its compatibility with amorphous valsartan. This pharmacologically relevant drug combination is a potential candidate for fixed-dose combination formulation.

Methods

DSC and TMDSC were used to examine thermal behavior of bisoprolol fumarate. SSNMR and XRPD were applied to probe the solid state forms. The thermal behavior of physical mixtures with different concentrations of bisoprolol and valsartan were examined by DSC and TMDSC, and the observed interactions were investigated by XRPD, solution- and solid-state NMR.

Results

The phase transitions from thermal methods and solid-state NMR spectra of crystalline and amorphous bisoprolol fumarate ar

SUBMITTER: Skotnicki M 

PROVIDER: S-EPMC4300422 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature