Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope.

ABSTRACT:

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The high-mannose patch of human immunodeficiency virus (HIV) envelope (Env) elicits broadly neutralizing antibodies (bnAbs) during natural infection relatively frequently, and consequently, this region has become a major target of vaccine design. However, it has also become clear that antibody recognition of the region is complex due, at least in part, to variability in neighboring loops and glycans critical to the epitopes. bnAbs against this region have some shared features and some distinguishing features that are crucial to understand in order to design optimal immunogens that can induce different classes of bnAbs against this region. Here, we compare two branches of a single antibody lineage, in which all members recognize the high-mannose patch. One branch (prototy

SUBMITTER: Doores KJ 

PROVIDER: S-EPMC4300629 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature