Replication of boid inclusion body disease-associated arenaviruses is temperature sensitive in both boid and mammalian cells.

ABSTRACT:

Unlabelled

Boid inclusion body disease (BIDB) is a fatal disease of boid snakes, the etiology of which has only recently been revealed following the identification of several novel arenaviruses in diseased snakes. BIBD-associated arenaviruses (BIBDAV) are genetically divergent from the classical Old and New World arenaviruses and also differ substantially from each other. Even though there is convincing evidence that BIBDAV are indeed the etiological agent of BIBD, the BIBDAV reservoir hosts--if any exist besides boid snakes themselves--are not yet known. In this report, we use University of Helsinki virus (UHV; a virus that we isolated from a Boa constrictor with BIBD) to show that BIBDAV can also replicate effectively in mammalian cells, including human cells, provided they are c

SUBMITTER: Hepojoki J 

PROVIDER: S-EPMC4300630 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature