Identifying structural variation in haploid microbial genomes from short-read resequencing data using breseq.

ABSTRACT:

Background

Mutations that alter chromosomal structure play critical roles in evolution and disease, including in the origin of new lifestyles and pathogenic traits in microbes. Large-scale rearrangements in genomes are often mediated by recombination events involving new or existing copies of mobile genetic elements, recently duplicated genes, or other repetitive sequences. Most current software programs for predicting structural variation from short-read DNA resequencing data are intended primarily for use on human genomes. They typically disregard information in reads mapping to repeat sequences, and significant post-processing and manual examination of their output is often required to rule out false-positive predictions and precisely describe mutational events.

Results

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SUBMITTER: Barrick JE 

PROVIDER: S-EPMC4300727 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature