The enterovirus 71 procapsid binds neutralizing antibodies and rescues virus infection in vitro.

ABSTRACT:

Unlabelled

Enterovirus 71 (EV71) is responsible for seasonal outbreaks of hand, foot, and mouth disease in the Asia-Pacific region. The virus has the capability to cause severe disease and death, especially in young children. Although several vaccines are currently in clinical trials, no vaccines or therapeutics have been approved for use. Previous structural studies have revealed that two antigenically distinct capsid forms are produced in EV71-infected cells: an expanded empty capsid, sometimes called a procapsid, and the infectious virus. Specifically, an immunodominant epitope of EV71 that maps to the virus canyon is structurally different in the procapsid and virus. This structure-function study shows that the procapsid can sequester antibodies, thus enhancing EV71 infection i

SUBMITTER: Shingler KL 

PROVIDER: S-EPMC4300772 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature