Ontology highlight
ABSTRACT:
SUBMITTER: Santos WL
PROVIDER: S-EPMC4301069 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
ACS chemical biology 20141119 1
The transfer of the gamma phosphate from ATP to sphingosine (Sph) to generate a small signaling molecule, sphingosine 1-phosphate (S1P), is catalyzed by sphingosine kinases (SphK), which exist as two isoforms, SphK1 and SphK2. SphK is a key regulator of S1P and the S1P:Sph/ceramide ratio. Increases in S1P levels have been linked to diseases including sickle cell disease, cancer, and fibrosis. Therefore, SphKs are potential targets for drug discovery. However, the current chemical biology toolkit ...[more]