New organocatalyst scaffolds with high activity in promoting hydrazone and oxime formation at neutral pH.

ABSTRACT: The discovery of two new classes of catalysts for hydrazone and oxime formation in water at neutral pH, namely 2-aminophenols and 2-(aminomethyl)benzimidazoles, is reported. Kinetics studies in aqueous solutions at pH 7.4 revealed rate enhancements up to 7-fold greater than with classic aniline catalysis. 2-(Aminomethyl)benzimidazoles were found to be effective catalysts with otherwise challenging aryl ketone substrates.

SUBMITTER: Larsen D 

PROVIDER: S-EPMC4301078 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature