Quantitative proteomics identifies host factors modulated during acute hepatitis E virus infection in the swine model.

ABSTRACT:

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Hepatitis E virus (HEV) causes acute enterically transmitted hepatitis. In industrialized countries, it is a zoonotic disease, with swine being the major reservoir of human HEV contamination. The occurrence and severity of the disease are variable, with clinical symptoms ranging from asymptomatic to self-limiting acute hepatitis, chronic infection, or fulminant hepatitis. In the absence of a robust cell culture system or small-animal models, the HEV life cycle and pathological process remain unclear. To characterize HEV pathogenesis and virulence mechanisms, a quantitative proteomic analysis was carried out to identify cellular factors and pathways modulated during acute infection of swine. Three groups of pigs were inoculated with three different strains of swine HEV to

SUBMITTER: Rogee S 

PROVIDER: S-EPMC4301096 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature