Contact-induced mitochondrial polarization supports HIV-1 virological synapse formation.

ABSTRACT:

Unlabelled

Rapid HIV-1 spread between CD4 T lymphocytes occurs at retrovirus-induced immune cell contacts called virological synapses (VS). VS are associated with striking T cell polarization and localized virus budding at the site of contact that facilitates cell-cell spread. In addition to this, spatial clustering of organelles, including mitochondria, to the contact zone has been previously shown. However, whether cell-cell contact specifically induces dynamic T cell remodeling during VS formation and what regulates this process remain unclear. Here, we report that contact between an HIV-1-infected T cell and an uninfected target T cell specifically triggers polarization of mitochondria concomitant with recruitment of the major HIV-1 structural protein Gag to the site of cell-ce

SUBMITTER: Groppelli E 

PROVIDER: S-EPMC4301097 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature