Merkel cell polyomavirus small T antigen mediates microtubule destabilization to promote cell motility and migration.

ABSTRACT:

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Merkel cell carcinoma (MCC) is an aggressive skin cancer of neuroendocrine origin with a high propensity for recurrence and metastasis. Merkel cell polyomavirus (MCPyV) causes the majority of MCC cases due to the expression of the MCPyV small and large tumor antigens (ST and LT, respectively). Although a number of molecular mechanisms have been attributed to MCPyV tumor antigen-mediated cellular transformation or replication, to date, no studies have investigated any potential link between MCPyV T antigen expression and the highly metastatic nature of MCC. Here we use a quantitative proteomic approach to show that MCPyV ST promotes differential expression of cellular proteins implicated in microtubule-associated cytoskeletal organization and dynamics. Intriguingly, we de

SUBMITTER: Knight LM 

PROVIDER: S-EPMC4301106 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature