A view of the E2-CD81 interface at the binding site of a neutralizing antibody against hepatitis C virus.

ABSTRACT:

Unlabelled

Hepatitis C virus (HCV) glycoprotein E2 is considered a major target for generating neutralizing antibodies against HCV, primarily due to its role of engaging host entry factors, such as CD81, a key cell surface protein associated with HCV entry. Based on a series of biochemical analyses in combination with molecular docking, we present a description of a potential binding interface formed between the E2 protein and CD81. The virus side of this interface includes a hydrophobic helix motif comprised of residues W(437)LAGLF(442), which encompasses the binding site of a neutralizing monoclonal antibody, mAb41. The helical conformation of this motif provides a structural framework for the positioning of residues F442 and Y443, serving as contact points for the interaction wi

SUBMITTER: Harman C 

PROVIDER: S-EPMC4301129 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature