High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study.

ABSTRACT:

Objective

To evaluate the diagnosis of myocardial infarction using a high sensitivity troponin I assay and sex specific diagnostic thresholds in men and women with suspected acute coronary syndrome.

Design

Prospective cohort study.

Setting

Regional cardiac centre, United Kingdom.

Participants

Consecutive patients with suspected acute coronary syndrome (n=1126, 46% women). Two cardiologists independently adjudicated the diagnosis of myocardial infarction by using a high sensitivity troponin I assay with sex specific diagnostic thresholds (men 34 ng/L, women 16 ng/L) and compared with current practice where a contemporary assay (50 ng/L, single threshold) was used to guide care.

Main outcome measure

Diagnosis of myocardial infarction.

Results

The hi

SUBMITTER: Shah AS 

PROVIDER: S-EPMC4301191 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature