PI3K/Akt signalling-mediated protein surface expression sensed by 14-3-3 interacting motif.

ABSTRACT: The regulation of protein expression on the cell surface membrane is an important component of the cellular response to extracellular signalling. The translation of extracellular signalling into specific protein localization often involves the post-translational modification of cargo proteins. Using a genetic screen of random peptides, we have previously identified a group of C-terminal sequences, represented by RGRSWTY-COOH (termed'SWTY'), which are capable of overriding an endoplasmic reticulum localization signal and directing membrane proteins to the cell surface via specific binding to 14-3-3 proteins. The identity of the kinase signalling pathways that drive phosphorylation and 14-3-3 binding of the SWTY sequence is not known. In this study, we report that the activation of the phosp

SUBMITTER: Chung JJ 

PROVIDER: S-EPMC4301307 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature