An analysis of the association between a polymorphism of KCNJ11 and diabetic retinopathy in a Chinese Han population.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have reported that the polymorphism rs5219 of the potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) is associated with type 2 diabetes mellitus (T2DM). Given that diabetic retinopathy (DR) is one of the most common microvascular complications of T2DM, GWAS have identified a number of potential susceptibility genes for DR. However, only a fraction of them have been replicated in different studies and show consistent genetic associations with the occurrence of DR. The aim of the present study was to investigate whether common variants of KCNJ11 confer DR in a cohort of the Chinese Han population.

Methods

A case-control study of 580 T2DM patients, including 105 T2DM with DR and 475 T2DM without DR was perfor

SUBMITTER: Liu NJ 

PROVIDER: S-EPMC4301311 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature