Current and recent clinical trials for perioperative systemic therapy for muscle invasive bladder cancer: a systematic review.

ABSTRACT:

Background

Although Muscle Invasive Bladder Cancer (MIBC) is increasing in incidence, treatment has largely remained limited to radical cystectomy with or without cisplatin-based neoadjuvant and/or adjuvant chemotherapy. We reviewed the current and recent clinical trials evaluating perioperative chemotherapy, targeted therapy, and novel therapeutic regimens for MIBC patients undergoing radical cystectomy.

Methods

An overview of perioperative MIBC management was conducted initially using MEDLINE. The Clinical Trials Registry and MEDLINE were further searched specifically for perioperative MIBC chemotherapy, targeted therapy, and other novel therapeutic approaches. Trials involving non-perioperative management, operative management other than radical cystectomy, multiple tumor

SUBMITTER: Vashistha V 

PROVIDER: S-EPMC4301463 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature