Ontology highlight
ABSTRACT:
SUBMITTER: Hao C
PROVIDER: S-EPMC4301580 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Cancer letters 20141118 1
Molecular annotated patient-derived xenograft (PDX) models are useful for the preclinical investigation of anticancer drugs and individualized anticancer therapy. We established 23 PDXs from 88 surgical specimens of lung cancer patients and determined gene mutations in these PDXs and their paired primary tumors by ultradeep exome sequencing on 202 cancer-related genes. The numbers of primary tumors with deleterious mutations in TP53, KRAS, PI3KCA, ALK, STK11, and EGFR were 43.5%, 21.7%, 17.4%, 1 ...[more]