Brain alterations within the first 100 days of HIV infection.

ABSTRACT:

Objective

Brain involvement is a serious complication of HIV infection. The earliest changes in the brain, which represents an anatomic site for viral persistence, are largely unknown.

Methods

This investigation used quantitative Magnetic Resonance methodologies, including high resolution and diffusion tensor (DTI) imaging, to evaluate the brain in 15 HIV and 20 seronegative subjects. All HIV subjects were antibody nonreactive with assay-estimated infection duration of less than 100 days.

Results

Brain volumetric analysis revealed reduced parenchyma with enlargement of the third ventricle and brainstem. DTI quantified loss of white matter integrity in the corpus callosum and diffusion alterations in caudate. Cognitive differences were indicated in psychomotor speed an

SUBMITTER: Ragin AB 

PROVIDER: S-EPMC4301670 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature