Cost-effectiveness of population screening for BRCA mutations in Ashkenazi jewish women compared with family history-based testing.

ABSTRACT:

Background

Population-based testing for BRCA1/2 mutations detects the high proportion of carriers not identified by cancer family history (FH)-based testing. We compared the cost-effectiveness of population-based BRCA testing with the standard FH-based approach in Ashkenazi Jewish (AJ) women.

Methods

A decision-analytic model was developed to compare lifetime costs and effects amongst AJ women in the UK of BRCA founder-mutation testing amongst: 1) all women in the population age 30 years or older and 2) just those with a strong FH (≥10% mutation risk). The model assumes that BRCA carriers are offered risk-reducing salpingo-oophorectomy and annual MRI/mammography screening or risk-reducing mastectomy. Model probabilities utilize the Genetic Cancer Prediction through Populatio

SUBMITTER: Manchanda R 

PROVIDER: S-EPMC4301704 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature