Fast individual ancestry inference from DNA sequence data leveraging allele frequencies for multiple populations.

ABSTRACT:

Background

Estimation of individual ancestry from genetic data is useful for the analysis of disease association studies, understanding human population history and interpreting personal genomic variation. New, computationally efficient methods are needed for ancestry inference that can effectively utilize existing information about allele frequencies associated with different human populations and can work directly with DNA sequence reads.

Results

We describe a fast method for estimating the relative contribution of known reference populations to an individual's genetic ancestry. Our method utilizes allele frequencies from the reference populations and individual genotype or sequence data to obtain a maximum likelihood estimate of the global admixture proportions using the

SUBMITTER: Bansal V 

PROVIDER: S-EPMC4301802 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature