Cross-species transcriptomic analysis elucidates constitutive aryl hydrocarbon receptor activity.

ABSTRACT:

Background

Research on the aryl hydrocarbon receptor (AHR) has largely focused on variations in toxic outcomes resulting from its activation by halogenated aromatic hydrocarbons. But the AHR also plays key roles in regulating pathways critical for development, and after decades of research the mechanisms underlying physiological regulation by the AHR remain poorly characterized. Previous studies identified several core genes that respond to xenobiotic AHR ligands across a broad range of species and tissues. However, only limited inferences have been made regarding its role in regulating constitutive gene activity, i.e. in the absence of exogenous ligands. To address this, we profiled transcriptomic variations between AHR-active and AHR-less-active animals in the absence of an exoge

SUBMITTER: Sun RX 

PROVIDER: S-EPMC4301818 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature