Association of INSIG2 polymorphism with overweight and LDL in children.

ABSTRACT:

Background

Dyslipidemia and overweight are common issues in children. Identifying genetic markers of risk could lead to targeted interventions. A polymorphism of SNP rs7566605 near insulin-induced gene 2 (INSIG2) has been identified as a strong candidate gene for obesity, through its feedback control of lipid synthesis.

Objective

To identify polymorphisms in INSIG2 which are associated with overweight (BMI ≥ 85% for age) and dyslipidemia in children.

Hypothesis

The C allele of rs7566605 would be significantly associated with BMI and LDL.

Design/methods

We genotyped 15 SNPs in/near INSIG2 in 1,058 healthy children (53% non-Hispanic white (NHW), 37% overweight) participating in a school based study. Genotype was compared with BMI and lipid markers, adjusting for

SUBMITTER: Kaulfers AM 

PROVIDER: S-EPMC4301876 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature