Longitudinal measurement of airway inflammation over one year in children and adults with intermittent asthma.

ABSTRACT:

Background

Asthma is an inflammatory disease of the airways, but in clinical practice inflammation is rarely monitored. The aim of this study was to assess the level of airway inflammation in steroid naïve adult and pediatric patients with intermittent asthma over one year.

Methods

54 children and 50 adults with intermittent asthma (GINA step 1) were included. On up to 6 visits lung function, airway hyperresponsiveness to methacholine (PC20FEV1), sputum eosinophils and exhaled nitric oxide (FeNO) were assessed.

Results

36 pediatric and 34 adult patients were able to produce at least three adequate sputum samples over the study period and were included into the analysis.In 8 children (22%) the percentage of sputum eosinophils was always below 2.5%. A higher level of eo

SUBMITTER: Pedersen F 

PROVIDER: S-EPMC4301900 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature