Global estimates of prevalent and incident herpes simplex virus type 2 infections in 2012.

ABSTRACT:

Background

Herpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital ulcers. Neonatal infection has high morbidity and mortality. Additionally, HSV-2 likely contributes substantially to the spread of HIV infection. The global burden of HSV-2 infection was last estimated for 2003. Here we present new global estimates for 2012 of the burden of prevalent (existing) and incident (new) HSV-2 infection among females and males aged 15-49 years, using updated methodology to adjust for test performance and estimate by World Health Organization (WHO) region.

Methods and findings

We conducted a literature review of HSV-2 prevalence studies world-wide since 2000. We then fitted a model with constant H

SUBMITTER: Looker KJ 

PROVIDER: S-EPMC4301914 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature