Cross-species toxicogenomic analyses and phenotypic anchoring in response to groundwater low-level pollution.

ABSTRACT:

Background

Comparison of toxicogenomic data facilitates the identification of deregulated gene patterns and maximizes health risk prediction in human.

Results

Here, we performed phenotypic anchoring on the effects of acute exposure to low-grade polluted groundwater using mouse and zebrafish. Also, we evaluated two windows of chronic exposure in mouse, starting in utero and at the end of lactation. Bioinformatic analysis of livers microarray data showed that the number of deregulated biofunctions and pathways is higher after acute exposure, compared to the chronic one. It also revealed specific profiles of altered gene expression in all treatments, pointing to stress response/mitochondrial pathways as major players of environmental toxicity. Of note, dysfunction of steroid ho

SUBMITTER: Porreca I 

PROVIDER: S-EPMC4301944 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature