Neurophysiological correlates of sevoflurane-induced unconsciousness.

ABSTRACT:

Background

Recent studies of anesthetic-induced unconsciousness in humans have focused predominantly on the intravenous drug propofol and have identified anterior dominance of alpha rhythms and frontal phase-amplitude coupling patterns as neurophysiological markers. However, it is unclear whether the correlates of propofol-induced unconsciousness are generalizable to inhaled anesthetics, which have distinct molecular targets and which are used more commonly in clinical practice.

Methods

The authors recorded 64-channel electroencephalograms in healthy human participants during consciousness, sevoflurane-induced unconsciousness, and recovery (n = 10; n = 7 suitable for analysis). Spectrograms and scalp distributions of low-frequency (1 Hz) and alpha (10 Hz) power were analyzed

SUBMITTER: Blain-Moraes S 

PROVIDER: S-EPMC4301983 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature