Impaired IKs channel activation by Ca(2+)-dependent PKC shows correlation with emotion/arousal-triggered events in LQT1.

ABSTRACT:

Background

The most common inherited cardiac arrhythmia, LQT1, is due to IKs potassium channel mutations and is linked to high risk of adrenergic-triggered cardiac events. We recently showed that although exercise-triggered events are very well treated by ß-blockers for these patients, acute arousal-triggered event rate were not significantly reduced after beta-blocker treatment, suggesting that the mechanisms underlying arousal-triggered arrhythmias may be different from those during exercise. IKs is strongly regulated by β-adrenergic receptor (β-AR) signaling, but little is known about the role of α1-AR-mediated regulation.

Methods and results

Here we show, using a combination of cellular electrophysiology and computational modeling, that IKs phosphorylation and α1-AR regu

SUBMITTER: O-Uchi J 

PROVIDER: S-EPMC4302024 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature